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“Understanding patient-specific disease mechanisms to develop improved cancer-targeting strategies”

Our research

The overall aim of the Maurice lab is to gain a fundamental understanding of the dual nature of signals that guide homeostatic tissue renewal and cancer cell growth. In healthy tissue renewal, a handful of signalling pathways supports the maintenance of small populations of adult stem cells. Deregulation of these pathways due to mutations is strongly linked to cancer development. Our main focus is to investigate how patient-derived mutations alter protein activity to promote the initiation and progression of cancer growth. With these insights we aim to uncover patient-specific disease mechanisms and develop improved cancer-targeting strategies. To address these issues, we combine advanced gene editing, proteomics, biochemistry and imaging approaches with organoid-based disease models.


News

PhD defense Anton Venhuizen

On Wednesday, May 7, Anton Venhuizen successfully defended his PhD thesis titled “Molecular Mechanisms of the β-Catenin Destruction Complex in Health and Disease”. We congratulate Anton on this important achievement and wish him much success and enjoyment in his new postdoctoral position at the Cambridge Institute for Medical Research.

PhD defense Felix van der Krift

On Tuesday, March 11, Felix van der Krift successfully defended his PhD thesis titled “Folate metabolism in cancer: New opportunities and strategies to exploit metabolic vulnerabilities”. We congratulate Felix on this significant achievement and wish him all the best in his new postdoctoral position at the Netherlands Cancer Institute (NKI).

Climbing for a Cause – Alpe d’HuZes 2025 

We’re proud to share that Prof. Madelon Maurice and postdocs Michiel Boekhout and Jelte van der Vaart will be participating in Alpe d’HuZes 2025, representing the Center for Molecular Medicine and Oncode Institute. On June 5th, they’ll be taking on the challenge of running or cycling up the legendary Alpe d’Huez—multiple times in one day—to raise funds for cancer […]

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Prof. Madelon Maurice – © LaLoes fotografie

Scientific training and positions

Current other activities

Prof. Madelon Maurice

Madelon Maurice is Professor of Molecular Cell Biology at the Center for Molecular Medicine of the University Medical Center Utrecht and a member of the Oncode Institute. Her group addresses key research questions in the fields of stem cell and cancer cell biology, using a multiscale approach in which structural and functional insights at the level of individual proteins are translated to the cellular and complex tissue level. The main interests of the Maurice group are to acquire a mechanistic understanding of major signalling pathways that control stem cell maintenance and tissue renewal and to investigate how patient-derived mutations impact on signal relay events to drive cancer growth. With these approaches the Maurice lab aims to contribute to novel paradigms on signalling and mutation-induced tumour progression and to the development of improved anti-cancer strategies.

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