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“Understanding patient-specific disease mechanisms to develop improved cancer-targeting strategies”

Our research

The overall aim of the Maurice lab is to gain a fundamental understanding of the dual nature of signals that guide homeostatic tissue renewal and cancer cell growth. In healthy tissue renewal, a handful of signalling pathways supports the maintenance of small populations of adult stem cells. Deregulation of these pathways due to mutations is strongly linked to cancer development. Our main focus is to investigate how patient-derived mutations alter protein activity to promote the initiation and progression of cancer growth. With these insights we aim to uncover patient-specific disease mechanisms and develop improved cancer-targeting strategies. To address these issues, we combine advanced gene editing, proteomics, biochemistry and imaging approaches with organoid-based disease models.


News

fluorescently stained organoids

2 Postdoctoral researcher positions

We’re hiring! We have 2 postdoc positions available at the crossroads of #stemcellbiology, #regeneration and #cancerdevelopment

Welcome Susanna

In February 2021 Susanna Plugge joined our lab as a PhD student working on LKB1 mutations in Peutz Jegher Syndrome

organoids intestinal regeneration

Review on modeling intestinal regeneration

We published a new review in Cell Death and Differentiation on Organoid-based modeling of intestinal development, regeneration, and repair.

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Prof. Madelon Maurice – © LaLoes fotografie

Scientific training and positions

Current other activities

Prof. Madelon Maurice

Madelon Maurice is Professor of Molecular Cell Biology at the Center for Molecular Medicine of the University Medical Center Utrecht and a member of the Oncode Institute. Her group addresses key research questions in the fields of stem cell and cancer cell biology, using a multiscale approach in which structural and functional insights at the level of individual proteins are translated to the cellular and complex tissue level. The main interests of the Maurice group are to acquire a mechanistic understanding of major signalling pathways that control stem cell maintenance and tissue renewal and to investigate how patient-derived mutations impact on signal relay events to drive cancer growth. With these approaches the Maurice lab aims to contribute to novel paradigms on signalling and mutation-induced tumour progression and to the development of improved anti-cancer strategies.

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