“Understanding patient-specific disease mechanisms to develop improved cancer-targeting strategies”

Our research

The overall aim of the Maurice lab is to gain a fundamental understanding of the dual nature of signals that guide homeostatic tissue renewal and cancer cell growth. In healthy tissue renewal, a handful of signalling pathways supports the maintenance of small populations of adult stem cells. Deregulation of these pathways due to mutations is strongly linked to cancer development. Our main focus is to investigate how patient-derived mutations alter protein activity to promote the initiation and progression of cancer growth. With these insights we aim to uncover patient-specific disease mechanisms and develop improved cancer-targeting strategies. To address these issues, we combine advanced gene editing, proteomics, biochemistry and imaging approaches with organoid-based disease models.


Lab retreat

On the 8th and 9th of June, the Maurice lab went on a lab retreat in the beautiful surroundings of Gun located in Limburg. We stayed at an old farm where we spend two days talking about science, getting to know each other better and doing fun activities. We made a nice overview of all […]

Goodbye Peter!

After more than 40 years (!) employed by the UMC Utrecht, our lab manager Peter van Kerkhof retired. We are very happy that he joined us in the Maurice team for the last years of his career. Working at UMC Utrecht for such a long time is of course something very special. Therefore we decided […]


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Prof. Madelon Maurice – © LaLoes fotografie

Scientific training and positions

Current other activities

Prof. Madelon Maurice

Madelon Maurice is Professor of Molecular Cell Biology at the Center for Molecular Medicine of the University Medical Center Utrecht and a member of the Oncode Institute. Her group addresses key research questions in the fields of stem cell and cancer cell biology, using a multiscale approach in which structural and functional insights at the level of individual proteins are translated to the cellular and complex tissue level. The main interests of the Maurice group are to acquire a mechanistic understanding of major signalling pathways that control stem cell maintenance and tissue renewal and to investigate how patient-derived mutations impact on signal relay events to drive cancer growth. With these approaches the Maurice lab aims to contribute to novel paradigms on signalling and mutation-induced tumour progression and to the development of improved anti-cancer strategies.

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