“Understanding patient-specific disease mechanisms to develop improved cancer-targeting strategies”
The overall aim of the Maurice lab is to gain a fundamental understanding of the dual nature of signals that guide homeostatic tissue renewal and cancer cell growth. In healthy tissue renewal, a handful of signalling pathways supports the maintenance of small populations of adult stem cells. Deregulation of these pathways due to mutations is strongly linked to cancer development. Our main focus is to investigate how patient-derived mutations alter protein activity to promote the initiation and progression of cancer growth. With these insights we aim to uncover patient-specific disease mechanisms and develop improved cancer-targeting strategies. To address these issues, we combine advanced gene editing, proteomics, biochemistry and imaging approaches with organoid-based disease models.
Scientific training and positions
• Oncode Investigator since 2017
• Principal Investigator at the Center for Molecular Medicine, University Medical Center since 2014
• Professor of Molecular Cell Biology at the University Medical Center Utrecht since 2016
• Recipient of VICI career grant in 2015
• Associate Professor (2012 – 2016) at the department of Cell Biology at the University Medical Center Utrecht
• Assistant Professor (2006 – 2012) at the department of Cell Biology at the University Medical Center Utrecht
• Recipient of ERC Starting grant in 2009
• Senior postdoc (2001 – 2005) in the group of Prof. Hans Clevers, Hubrecht Institute, Utrecht
• Postdoc (1998 – 2001) in the group of Prof. Hidde Ploegh, Harvard Medical School, Boston, USA
• PhD (1993-1998) in the group of Prof. Dr. Cor Verweij at Leiden University
Current other activities
• Member of the Research Management Committee of the Oncode Institute
• Member of the Programme Council of Utrecht Life Sciences
• Member of the scientific board at KWF (Dutch Cancer Society)
• Co-director of the Utrecht Platform for Organoid Technology (U-PORT)
Prof. Madelon Maurice
Madelon Maurice is Professor of Molecular Cell Biology at the Center for Molecular Medicine of the University Medical Center Utrecht and a member of the Oncode Institute. Her group addresses key research questions in the fields of stem cell and cancer cell biology, using a multiscale approach in which structural and functional insights at the level of individual proteins are translated to the cellular and complex tissue level. The main interests of the Maurice group are to acquire a mechanistic understanding of major signalling pathways that control stem cell maintenance and tissue renewal and to investigate how patient-derived mutations impact on signal relay events to drive cancer growth. With these approaches the Maurice lab aims to contribute to novel paradigms on signalling and mutation-induced tumour progression and to the development of improved anti-cancer strategies.
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