Van der Krift F, Zijlmans DW, Shukla R, Javed A, Koukos PI, Schwarz LLE, Timmermans-Sprang EPM, Maas PEM, Gahtory D, Van den Nieuwboer M, Mol J, Strous GJ, Bonvin AMJJ, Van der Stelt M, Veldhuizen EJA, Weingarth M, Vermeulen M, Klumperman J, Maurice MM. “A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance”. BioRxiv preprint
Bugter JM, El Bouazzaoui L, Küçükköse E, Hong Y, Sprangers J, Jordens I, Fenderico N, Montiel Gonzalez D, Van Boxtel R, Suijkerbuijk SJE, Tejpar S, Snippert HJG, Kranenburg O, Maurice MM. “RNF43 mutations facilitate mucinous colorectal cancer metastasis via formation of a tumour-intrinsic niche”. BioRxiv preprint
Van Kerkhof P, Kralj T, Spanevello F, Van Bloois L, Jordens I, Van der Vaart J, Jamieson C, Merenda A, Mastrobattista E, Maurice MM. “RSPO3 Furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells”. Journal of Controlled Release (2023). PMID: 36813038
2022
Houtekamer RM, van der Net MC,Maurice MM, Gloerich M. “Mechanical forces directing intestinal form and function”. Current Biology (2022). PMID: 35882203.
2021
Venhuizen AJ, van der Krift, F, Maurice MM. “Building a complex for destruction”. Molecular Cell (2021). PMID: 34416136.
2020
Pascual R, Segura-Morales C, Omerzu M, Bellora N, Belloc E, Castellazzi CL, Reina O, Eyras E, Maurice MM, Millanes-Romero A, Méndez R. “mRNA spindle localization and mitotic translational regulation by CPEB1 and CPEB4. RNA”. RNA (2020). PMID: 33323527.
Sprangers J, Zaalberg IC, Maurice MM. “Organoid-based modeling of intestinal development, regeneration, and repair”. Cell Death and Differentiation (2020). PMID: 33208888
Ludikhuize MC, Meerlo M, Gallego MP, Xanthakis D, Burgaya Julià M, Nguyen NTB, Brombacher EC, Liv N, Maurice MM, Paik JH, Burgering BMT, Rodriguez Colman MJ. “Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis”. Cell Metabolism (2020). PMID: 33147486
Bugter JM, Fenderico N, Maurice MM “Mutations and mechanisms of WNT pathway tumour suppressors in cancer”. Nature Reviews Cancer (2020). PMID: 33097916
Spit M., Fenderico N., Jordens I., Radaszkiewicz T., Lindeboom R.G., Bugter J.M., Cristobal A., Ootes L., van Osch M., Janssen E., Boonekamp K.E., Hanakova K., Potesil D., Zdrahal Z., Boj S.F., Medema J.P., Bryja V., Koo B., Vermeulen M., & Maurice M.M. “RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer.”. The EMBO Journal (2020). PMID: 32965059
Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R. “R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.”. Elife (2020). PMID: 32432544
Novellasdemunt L, Kucharska A, Jamieson C, Prange-Barczynska M, Baulies A, Antas P, van der Vaart J, Gehart H, Maurice MM, Li VS. “NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.”. The EMBO journal (2020). PMID: 31867777
Merenda A, Fenderico N, Maurice MM. “Wnt Signaling in 3D: Recent Advances in the Applications of Intestinal Organoids.”. Trends in cell biology (2020). PMID: 31718893
2019
Omerzu M, Fenderico N, de Barbanson B, Sprangers J, de Ridder J, Maurice MM. “Three-dimensional analysis of single molecule FISH in human colon organoids.”. Biology open (2019). PMID: 31362950
Stanganello E, Zahavi EE, Burute M, Smits J, Jordens I, Maurice MM, Kapitein LC, Hoogenraad CC. “Wnt Signaling Directs Neuronal Polarity and Axonal Growth.”. iScience (2019). PMID: 30878878
Fenderico N, van Scherpenzeel RC, Goldflam M, Proverbio D, Jordens I, Kralj T, Stryeck S, Bass TZ, Hermans G, Ullman C, Aastrup T, Gros P, Maurice MM. “Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.”. Nature communications (2019). PMID: 30664649
2018
Spit M, Koo BK, Maurice MM. “Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer.”. Open biology (2018). PMID: 30209039
Gerlach JP, Jordens I, Tauriello DVF, van ‘t Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM. “TMEM59 potentiates Wnt signaling by promoting signalosome formation.”. Proceedings of the National Academy of Sciences of the United States of America (2018). PMID: 29632210
Oost KC, van Voorthuijsen L, Fumagalli A, Lindeboom RGH, Sprangers J, Omerzu M, Rodriguez-Colman MJ, Heinz MC, Verlaan-Klink I, Maurice MM, Burgering BMT, van Rheenen J, Vermeulen M, Snippert HJG. “Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.”. Cell reports (2018). PMID: 29425513
Ward ME, Daniëls MA, van Kappel EC, Maurice MM, Baldus M. “Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR.”. Chemical communications (2018). PMID: 29561051
Kievit A, Tessadori F, Douben H, Jordens I, Maurice M, Hoogeboom J, Hennekam R, Nampoothiri S, Kayserili H, Castori M, Whiteford M, Motter C, Melver C, Cunningham M, Hing A, Kokitsu-Nakata NM, Vendramini-Pittoli S, Richieri-Costa A, Baas AF, Breugem CC, Duran K, Massink M, Derksen PWB, van IJcken WFJ, van Unen L, Santos-Simarro F, Lapunzina P, Gil-da Silva Lopes VL, Lustosa-Mendes E, Krall M, Slavotinek A, Martinez-Glez V, Bakkers J, van Gassen KLI, de Klein A, van den Boogaard MH, van Haaften G. “Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.”. European journal of human genetics (2018). PMID: 29348693
2017
van Kappel EC, Maurice MM. “Molecular regulation and pharmacological targeting of the β-catenin destruction complex.”. British journal of pharmacology (2017). PMID: 28634996
van Andel H, Kocemba K, de Haan-Kramer A, Mellink C, Piwowar M, Broijl A, van Duin M, Sonneveld P, Maurice MM, Kersten MJ, and Spaargaren M, Pals ST. “Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease”., (2017) Oncogene (2017), PMID: 27775078
2016
Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM. “Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.”. Nature structural & molecular biology (2016). PMID: 26974125
Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H. “Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.”. Nature (2016). PMID: 26863187
2015
Massink MP, Créton MA, Spanevello F, Fennis WM, Cune MS, Savelberg SM, Nijman IJ, Maurice MM, van den Boogaard MJ, van Haaften G. “Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.”. American journal of human genetics (2015). PMID: 26387593
Zlatanou A, Miller E, Sabbioneda S, Greenwalt A, Aggathanggelou A, Maurice M, Lehmann A, Satnkovic T, Reverdy C, Colland F, Vaziri C, Stewart G, “USP7 is essential for maintaining Rad18 stability and DNA damage tolerance”, Oncogene, (2015), PMID: 25961918
2014
Gerlach JP, Emmink BL, Nojima H, Kranenburg O, Maurice MM. “Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.”. Open biology (2014). PMID: 25392450
Consonni SV, Maurice MM, Bos JL. “DEP domains: structurally similar but functionally different.”. Nature reviews. Molecular cell biology (2014). PMID: 24739740
2013
Minde DP, Radli M, Forneris F, Maurice MM, Rüdiger SG. “Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.”. PloS one (2013). PMID: 24130866
van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ, “Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity.”, Immunity (2013), PMID: 23973222
Jung H, Kim BG, Han WH, Lee JH, Cho JY, Park WS, Maurice MM, Han JK, Lee MJ, Finley D, Jho EH, “Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling”, Oncogenesis (2013), PMID: 23958854
van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ, “Canonical wnt signaling negatively modulates regulatory T cell function.”, Immunity (2013), PMID: 23954131
Xue B, Romero PR, Noutsou M, Maurice MM, Rüdiger SG, William AM, Mizianty MJ, Kurgan L, Uversky VN, Dunker AK. “Stochastic machines as a colocalization mechanism for scaffold protein function.”. FEBS letters (2013). PMID: 23603389
2012
Minde DP, Maurice MM, Rüdiger SG. “Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp.”. PloS one (2012). PMID: 23056252
Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H. “Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.”. Nature (2012). PMID: 22895187
Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H. “Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.”. Cell (2012). PMID: 22682247
Nethe M, de Kreuk BJ, Tauriello DV, Anthony EC, Snoek B, Stumpel T, Salinas PC, Maurice MM, Geerts D, Deelder AM, Hensbergen PJ, Hordijk PL. “Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.”. Journal of cell science (2012);125:3430-42. PMID: 22467858
Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM. “Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.”. Proceedings of the National Academy of Sciences of the United States of America (2012). PMID: 22411803
2011
Minde DP, Anvarian Z, Rüdiger SG, Maurice MM. “Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer.”. Molecular cancer (2011). PMID: 21859464
Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SG, Maurice MM. “Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded.”. Journal of molecular biology (2011). PMID: 21087614
2010
Tauriello DV, Maurice MM. “The various roles of ubiquitin in Wnt pathway regulation.”. Cell cycle (2010). PMID: 20930545
Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM. “Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.”. Molecular cell (2010). PMID: 20227366