Publications

2024

  • Venhuizen AJ, van Os Y, Kaptein ML, Aarts MT, Xanthakis D, Jordens I, Maurice MM. “Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling”. BioRxiv preprint
  • Sprangers J, Bugter JM, Xanthakis D, Boekhout M, Kok RNU, Brosens LAA, Dijk F, Rodriguez Colman MJ, van der Vaart JY, Maurice MM. “WNT7B drives a program for pancreatic cancer subtype switching and progression”. BioRxiv preprint
  • Bugter JM, van Kerkhof P, Jordens I, Janssen E, Tran Ngoc Minh T, Iglesias van Montfort D, Jamieson C, Maurice MM. “E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors”. Life Science Alliance (2024). PMID: 38969364

2023

  • Plugge SF, Ma H, van der Vaart JY, Sprangers J, Morsink FHM, Xanthakis D, Jamieson C, Keijzer AR, Margaritis T, Candelli T, Straver R, De Ridder J, Holstege FCP, De Leng WWJ, Offerhaus GJA, Merenda A, Maurice MM. “Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway”. BioRxiv preprint
  • Terhal P, Venhuizen AJ, Lessel D, Tan WH, Alswaid A, Grün R, Alzaidan HI, Von Kroge S, Ragab N, Hempel M, Kubisch C, Novais E, Cristobal A, Tripolszki K, Bauer P, Fischer-Zirnsak B, Nievelstein RAJ, Van Dijk A, Nikkels P, Oheim R, Hahn H, Bertoli-Avella A, Maurice MM, Kornak U. “AXIN1 bi-allelic variants disrupting the C-terminal DIX domain cause craniometadiaphyseal osteosclerosis with hip dysplasia”. American Journal of Human Genetics (2023). PMID: 37582359
  • Van der Krift F, Zijlmans DW,  Shukla R, Javed A, Koukos PI, Schwarz LLE, Timmermans-Sprang EPM, Maas PEM, Gahtory D, Van den Nieuwboer M,  Mol J, Strous GJ, Bonvin AMJJ, Van der Stelt M, Veldhuizen EJA, Weingarth M, Vermeulen M,  Klumperman J, Maurice MM. “A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance”. Life Science Alliances (2023), PMID: 37591722
  • Bugter JM, El Bouazzaoui L, Küçükköse E,  Hong Y, Sprangers J,  Jordens I, Fenderico N, Montiel Gonzalez D,  Van Boxtel R, Suijkerbuijk SJE, Tejpar S, Snippert HJG, Kranenburg O, Maurice MM. “RNF43 mutations facilitate mucinous colorectal cancer metastasis via formation of a tumour-intrinsic niche”. BioRxiv preprint
  • Van Kerkhof P, Kralj T, Spanevello F, Van Bloois L, Jordens I, Van der Vaart J, Jamieson C, Merenda A, Mastrobattista E, Maurice MM. “RSPO3 Furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells”. Journal of Controlled Release (2023). PMID: 36813038

2022

  • Houtekamer RM, van der Net MC, Maurice MM, Gloerich M. “Mechanical forces directing intestinal form and function”. Current Biology (2022). PMID: 35882203.

2021

  • Venhuizen AJ, van der Krift, F, Maurice MM. “Building a complex for destruction”. Molecular Cell (2021). PMID: 34416136.

2020

  • Pascual R, Segura-Morales C, Omerzu M, Bellora N, Belloc E, Castellazzi CL, Reina O, Eyras E, Maurice MM, Millanes-Romero A, Méndez R. “mRNA spindle localization and mitotic translational regulation by CPEB1 and CPEB4. RNA”. RNA (2020). PMID: 33323527.
  • Sprangers J, Zaalberg IC, Maurice MM. “Organoid-based modeling of intestinal development, regeneration, and repair”. Cell Death and Differentiation (2020). PMID: 33208888
  • Ludikhuize MC, Meerlo M, Gallego MP, Xanthakis D, Burgaya Julià M, Nguyen NTB, Brombacher EC, Liv N, Maurice MM, Paik JH, Burgering BMT, Rodriguez Colman MJ. “Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis”. Cell Metabolism (2020). PMID: 33147486
  • Bugter JM, Fenderico N, Maurice MM “Mutations and mechanisms of WNT pathway tumour suppressors in cancer”. Nature Reviews Cancer (2020). PMID: 33097916
  • Spit M., Fenderico N., Jordens I., Radaszkiewicz T., Lindeboom R.G., Bugter J.M., Cristobal A., Ootes L., van Osch M., Janssen E., Boonekamp K.E., Hanakova K., Potesil D., Zdrahal Z., Boj S.F., Medema J.P., Bryja V., Koo B., Vermeulen M., & Maurice M.M. “RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer.”. The EMBO Journal (2020). PMID: 32965059
  • Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R. “R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.”. Elife (2020). PMID: 32432544
  • Novellasdemunt L, Kucharska A, Jamieson C, Prange-Barczynska M, Baulies A, Antas P, van der Vaart J, Gehart H, Maurice MM, Li VS. “NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.”. The EMBO journal (2020). PMID: 31867777
  • Merenda A, Fenderico N, Maurice MM. “Wnt Signaling in 3D: Recent Advances in the Applications of Intestinal Organoids.”. Trends in cell biology (2020). PMID: 31718893

2019

  • Omerzu M, Fenderico N, de Barbanson B, Sprangers J, de Ridder J, Maurice MM. “Three-dimensional analysis of single molecule FISH in human colon organoids.”. Biology open (2019). PMID: 31362950
  • Stanganello E, Zahavi EE, Burute M, Smits J, Jordens I, Maurice MM, Kapitein LC, Hoogenraad CC. “Wnt Signaling Directs Neuronal Polarity and Axonal Growth.”. iScience (2019). PMID: 30878878
  • Fenderico N, van Scherpenzeel RC, Goldflam M, Proverbio D, Jordens I, Kralj T, Stryeck S, Bass TZ, Hermans G, Ullman C, Aastrup T, Gros P, Maurice MM. “Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.”. Nature communications (2019). PMID: 30664649

2018

  • Spit M, Koo BK, Maurice MM. “Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer.”. Open biology (2018). PMID: 30209039
  • Gerlach JP, Jordens I, Tauriello DVF, van ‘t Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM. “TMEM59 potentiates Wnt signaling by promoting signalosome formation.”. Proceedings of the National Academy of Sciences of the United States of America (2018). PMID: 29632210
  • Oost KC, van Voorthuijsen L, Fumagalli A, Lindeboom RGH, Sprangers J, Omerzu M, Rodriguez-Colman MJ, Heinz MC, Verlaan-Klink I, Maurice MM, Burgering BMT, van Rheenen J, Vermeulen M, Snippert HJG. “Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.”. Cell reports (2018). PMID: 29425513
  • Ward ME, Daniëls MA, van Kappel EC, Maurice MM, Baldus M. “Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR.”. Chemical communications (2018). PMID: 29561051
  • Kievit A, Tessadori F, Douben H, Jordens I, Maurice M, Hoogeboom J, Hennekam R, Nampoothiri S, Kayserili H, Castori M, Whiteford M, Motter C, Melver C, Cunningham M, Hing A, Kokitsu-Nakata NM, Vendramini-Pittoli S, Richieri-Costa A, Baas AF, Breugem CC, Duran K, Massink M, Derksen PWB, van IJcken WFJ, van Unen L, Santos-Simarro F, Lapunzina P, Gil-da Silva Lopes VL, Lustosa-Mendes E, Krall M, Slavotinek A, Martinez-Glez V, Bakkers J, van Gassen KLI, de Klein A, van den Boogaard MH, van Haaften G. “Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.”. European journal of human genetics (2018). PMID: 29348693

2017

  • van Kappel EC, Maurice MM. “Molecular regulation and pharmacological targeting of the β-catenin destruction complex.”. British journal of pharmacology (2017). PMID: 28634996
  • van Andel H, Kocemba K, de Haan-Kramer A, Mellink C, Piwowar M, Broijl A, van Duin M, Sonneveld P, Maurice MM, Kersten MJ, and Spaargaren M, Pals ST. “Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease”., (2017) Oncogene (2017), PMID: 27775078

2016

  • Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM. “Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.”. Nature structural & molecular biology (2016). PMID: 26974125
  • Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H. “Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.”. Nature (2016). PMID: 26863187

2015

  • Massink MP, Créton MA, Spanevello F, Fennis WM, Cune MS, Savelberg SM, Nijman IJ, Maurice MM, van den Boogaard MJ, van Haaften G. “Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.”. American journal of human genetics (2015). PMID: 26387593
  • Zlatanou A, Miller E, Sabbioneda S, Greenwalt A, Aggathanggelou A, Maurice M, Lehmann A, Satnkovic T, Reverdy C, Colland F, Vaziri C, Stewart G, “USP7 is essential for maintaining Rad18 stability and DNA damage tolerance”, Oncogene, (2015), PMID: 25961918

2014

  • Gerlach JP, Emmink BL, Nojima H, Kranenburg O, Maurice MM. “Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.”. Open biology (2014). PMID: 25392450
  • Consonni SV, Maurice MM, Bos JL. “DEP domains: structurally similar but functionally different.”. Nature reviews. Molecular cell biology (2014). PMID: 24739740

2013

  • Minde DP, Radli M, Forneris F, Maurice MM, Rüdiger SG. “Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.”. PloS one (2013). PMID: 24130866
  • van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ, “Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity.”, Immunity (2013), PMID: 23973222
  • Jung H, Kim BG, Han WH, Lee JH, Cho JY, Park WS, Maurice MM, Han JK, Lee MJ, Finley D, Jho EH, “Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling”, Oncogenesis (2013), PMID: 23958854
  • van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ,
    “Canonical wnt signaling negatively modulates regulatory T cell function.”, Immunity (2013), PMID: 23954131
  • Xue B, Romero PR, Noutsou M, Maurice MM, Rüdiger SG, William AM, Mizianty MJ, Kurgan L, Uversky VN, Dunker AK. “Stochastic machines as a colocalization mechanism for scaffold protein function.”. FEBS letters (2013). PMID: 23603389

2012

  • Minde DP, Maurice MM, Rüdiger SG. “Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp.”. PloS one (2012). PMID: 23056252
  • Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H. “Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.”. Nature (2012). PMID: 22895187
  • Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H. “Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.”. Cell (2012). PMID: 22682247
  • Nethe M, de Kreuk BJ, Tauriello DV, Anthony EC, Snoek B, Stumpel T, Salinas PC, Maurice MM, Geerts D, Deelder AM, Hensbergen PJ, Hordijk PL. “Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.”. Journal of cell science (2012);125:3430-42. PMID: 22467858
  • Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM. “Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.”. Proceedings of the National Academy of Sciences of the United States of America (2012). PMID: 22411803

2011

  • Minde DP, Anvarian Z, Rüdiger SG, Maurice MM. “Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer.”. Molecular cancer (2011). PMID: 21859464
  • Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SG, Maurice MM. “Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded.”. Journal of molecular biology (2011). PMID: 21087614

2010

  • Tauriello DV, Maurice MM. “The various roles of ubiquitin in Wnt pathway regulation.”. Cell cycle (2010). PMID: 20930545
  • Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM. “Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.”. Molecular cell (2010). PMID: 20227366